RELATIONSHIP OF NEUTROPHIL LYMPHOCYTE RATIO WITH APPENDICITIS INCIDENCE Review of Appendicitis Patients at Ibnu Sina Hospital, Gresik Regency in 2022-2023

Authors

  • Akhmad Setyo Rahman Ibnu Sina Regional General Hospital
  • Taufan Harijanto Ibnu Sina Regional General Hospital
  • Dono Marsetio Ibnu Sina Regional General Hospital
  • Agung Kusuma Negara Ibnu Sina Regional General Hospital
  • Nur Lailatul Fadhilah Ibnu Sina Regional General Hospital

DOI:

https://doi.org/10.37010/nuc.v5i02.1776

Keywords:

NLR, appendicitis, complicata, uncomplicata

Abstract

This study aims to analyze the relationship between the neutrophil lymphocyte ratio (NLR) and the incidence of acute appendicitis in patients at Ibnu Sina Hospital, Gresik Regency, in the 2022-2023 period. Acute appendicitis is a frequent emergency surgical condition, especially in adolescents and young adults, with the risk of complications such as perforation and peritonitis. NLR, as an indicator of inflammatory response, is considered more practical and economical than CT scans and ultrasounds, which have limited cost, accessibility, and risk of radiation exposure. This study used an observational analytical method with a cross-sectional approach on 51 appendicitis patients who underwent appendectomy. NLR data was obtained through routine blood results, with statistical analysis using SPSS to test the normality and difference in NLR values between uncomplicated appendicitis and appendicitis with complications. There was a significant difference in the mean NLR value between patients with complementary and non-complementary appendicitis, with a p < value of 0.001. The results of the ROC Curve analysis show that NLR has a high prediction value in predicting complementary appendicitis of 97.5%. This study concludes that NLR can be an effective indicator in distinguishing cases of complementary and non-complementary appendicitis and the potential of NLR as an easy and efficient screening tool in the treatment of acute appendicitis, especially in health facilities with limited resources.

References

Acharya, A., et al. (2017). Biomarkers of acute appendicitis: systematic review and cost-benefit trade-off analysis. Surgical Endoscopy, 31(3), 1022–1031. https://doi.org/10.1007/s00464-016-5109-1

Adir, A., et al. (2024). The role of blood inflammatory markers in the preoperative diagnosis of acute appendicitis. International Journal of Laboratory Hematology, 46(1), 58–62. https://doi.org/10.1111/ijlh.14163

Ahmad, K. A., Ideris, N., & Abd Aziz, S. H. S. (2019). A cross-sectional study of neutrophil-to-lymphocyte ratio in diagnosing acute appendicitis in hospital Melaka. Malaysian Journal of Medical Sciences, 26(6), 55–66. https://doi.org/10.21315/mjms2019.26.6.6

Akbulut, S., et al. (2021). An investigation into the factors predicting acute appendicitis and perforated appendicitis. Ulusal Travma ve Acil Cerrahi Dergisi, 27(4), 434–442. https://doi.org/10.14744/tjtes.2020.60344

Al Amri, F. S., et al. (2023). Accuracy of neutrophil-to-lymphocyte ratio in predicting the severity of acute appendicitis: A single-center retrospective study. Cureus, 15(9), e45923. https://doi.org/10.7759/cureus.45923

Bhangu, A., et al. (2016). Acute appendicitis: Modern understanding of pathogenesis, diagnosis, and management. The Lancet, 386(10000), 1278–1287. https://doi.org/10.1016/S0140-6736(15)00275-5

Bom, W. J., et al. (2021). Diagnosis of uncomplicated and complicated appendicitis in adults. Scandinavian Journal of Surgery, 110(2), 170–179. https://doi.org/10.1177/14574969211008330

Buckius, M. T., et al. (2012). Changing epidemiology of acute appendicitis in the United States: Study period 1993-2008. The Journal of Surgical Research, 175(2), 185–190. https://doi.org/10.1016/j.jss.2011.07.017

Ferris, M., et al. (2017). The global incidence of appendicitis: A systematic review of population-based studies. Annals of Surgery, 266(2), 237–241. https://doi.org/10.1097/SLA.0000000000002188

Guan, L., et al. (2023). The global, regional, and national burden of appendicitis in 204 countries and territories, 1990–2019: A systematic analysis from the Global Burden of Disease Study 2019. BMC Gastroenterology, 23(1), 44. https://doi.org/10.1186/s12876-023-02678-7

Ha, S. C., et al. (2024). Blood biomarkers to distinguish complicated and uncomplicated appendicitis in pediatric patients. Journal of the Formosan Medical Association, 123(10), 1093–1098. https://doi.org/10.1016/j.jfma.2024.01.023

Hajibandeh, S., et al. (2020). Neutrophil-to-lymphocyte ratio predicts acute appendicitis and distinguishes between complicated and uncomplicated appendicitis: A systematic review and meta-analysis. The American Journal of Surgery, 219(1), 154–163. https://doi.org/10.1016/j.amjsurg.2019.04.018

Han, H., et al. (2024). Trends and levels of the global, regional, and national burden of appendicitis between 1990 and 2021: Findings from the Global Burden of Disease Study 2021. The Lancet Gastroenterology & Hepatology, 9(9), 825–858. https://doi.org/10.1016/S2468-1253(24)00157-2

Heise, J. W., et al. (2021). Laparoscopic appendectomy: A safe and definitive solution for suspected appendicitis. Visceral Medicine, 37(3), 180–188. https://doi.org/10.1159/000510487

Kahramanca, S., et al. (2014). Neutrophil-to-lymphocyte ratio as a predictor of acute appendicitis. Ulusal Travma ve Acil Cerrahi Dergisi, 20(1), 19–22. https://doi.org/10.5505/tjtes.2014.20688

Kollias, T. F., et al. (2024). Sex differences in appendicitis: A systematic review. Cureus, 16(5), e60055. https://doi.org/10.7759/cureus.60055

Liu, X., et al. (2016). Prognostic significance of neutrophil-to-lymphocyte ratio in patients with sepsis: A prospective observational study. Mediators of Inflammation, 2016, 8191254. https://doi.org/10.1155/2016/8191254

Peeters, T., et al. (2023). An observational study on lifestyle and environmental risk factors in patients with acute appendicitis. Heliyon, 9(4), e15131. https://doi.org/10.1016/j.heliyon.2023.e15131

Saridas, A., et al. (2024). Comparison of the ability of newly inflammatory markers to predict complicated appendicitis. Open Medicine (Poland, 19(1). https://doi.org/10.1515/med-2024-1002

Di Saverio, S., et al. (2020a). Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World Journal of Emergency Surgery, 15(1), 27. https://doi.org/10.1186/s13017-020-00306-3

Di Saverio, S., et al. (2020b). Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World Journal of Emergency Surgery, 15(1), 1–42. https://doi.org/10.1186/s13017-020-00306-3

Shogilev, D. J., et al. (2016). Diagnosing appendicitis: Evidence-based review of the diagnostic approach in 2014. The Western Journal of Emergency Medicine, 15(7), 859–871. https://doi.org/10.5811/westjem.2014.9.21568

W., S. C. (2015). CT scans: Balancing health risks and medical benefits. Environmental Health Perspectives, 120(3), a118–a121. https://doi.org/10.1289/ehp.120-a118

Whittle, C., et al. (2019). Appendicular lymphoid hyperplasia in the differential diagnosis of acute appendicitis: Sonographic findings. Journal of Diagnostic Medical Sonography, 36(1), 19–23. https://doi.org/10.1177/8756479319878235

Downloads

Published

2024-11-05

How to Cite

Rahman, A. S., Harijanto, T., Marsetio, D., Negara, A. K., & Fadhilah, N. L. (2024). RELATIONSHIP OF NEUTROPHIL LYMPHOCYTE RATIO WITH APPENDICITIS INCIDENCE Review of Appendicitis Patients at Ibnu Sina Hospital, Gresik Regency in 2022-2023. NUCLEUS, 5(02), 117–124. https://doi.org/10.37010/nuc.v5i02.1776

Issue

Section

Artikel
Abstract viewed = 28 times